| D | functional programming, imperative programming, object-oriented programming | 2001 | Walter Bright, D Language Foundation |
| DADiSP | multi-paradigm programming | — | — |
| Dafny | design by contract, imperative programming, functional programming | 2009 | K. Rustan M. Leino, Remy Willems, Daniel Matichuk |
| Dark | — | — | — |
| DarkBASIC | — | 2000 | The Game Creators |
| Dart | object-oriented programming, multi-paradigm programming, imperative programming, functional programming, reflective programming | 2011 | Google |
| Dartmouth BASIC | imperative programming | — | — |
| Darwin | imperative programming, structured programming, object-oriented programming | 1991 | — |
| Data Language Interface | — | 1966 | IBM |
| DataFlex | object-oriented programming, imperative programming, structured programming | 1982 | — |
| Datalog | declarative programming, logic programming | 1986 | — |
| DATATRIEVE | — | — | Hewlett-Packard |
| DBYTE | imperative programming, structured programming | — | — |
| Deadfish | esoteric programming | — | — |
| Deesel | — | — | — |
| Delegua | — | 2022 | — |
| Delphi | object-oriented programming | 1995 | Anders Hejlsberg |
| Delta COBOL | — | — | — |
| Design By Numbers | object-oriented programming | 1999 | John Maeda |
| Deterministic Parallel Java | — | — | — |
| Dhall | — | — | — |
| DIBOL | imperative programming, procedural programming, structured programming | 1970 | Digital Equipment Corporation |
| DIGITAL Command Language | imperative programming | — | Digital Equipment Corporation |
| Discipulus | — | 2012 | — |
| DIV Games Studio | — | 1998 | — |
| DJPROCODE | — | 2026 | Debojit Dev |
| Dog | — | — | Sepandar Kamvar |
| Dolittle | multi-paradigm programming | — | Osaka Electro-Communication University |
| DOPE | — | — | — |
| Draco | imperative programming, procedural programming, structured programming | — | — |
| Dragon | dynamic programming, object-oriented programming, imperative programming, procedural programming | 2018 | — |
| DRAKON | visual programming language | 1996 | — |
| Drools Rule Language | — | — | — |
| DuAL | — | 2004 | — |
| DUP programming language | functional programming | — | Ericsson |
| Dylan | object-oriented programming, multi-paradigm programming, functional programming | 1992 | Apple Inc., Carnegie Mellon University |
| DYNAMO | — | — | — |
| Dzaima APL | — | — | — |