| DD-WRT | — | — | GNU General Public License |
| Debian | The Debian Project | 1993 | GNU General Public License |
| Debian Edu | — | — | GNU General Public License |
| Debian Pure Blend | — | — | — |
| Deepin | — | 2016 | GNU General Public License |
| DEFT Linux | Stefano Fratepietro | — | GNU General Public License |
| Desinfec't | — | — | — |
| Deutsche Linux-Distribution | Dirk Haaga | — | — |
| Devil-Linux | — | — | — |
| Devuan | Dyne foundation | — | GNU General Public License |
| DGA4131 FW_248 | — | — | GNU General Public License, version 2.0 |
| DietPi | — | 2014 | — |
| Distro Astro | — | — | — |
| DNALinux | — | — | — |
| DoudouLinux | — | — | — |
| Dpup | — | — | — |
| Draco GNU/Linux | Ole-André Rodlie | — | 3-clause BSD License, GNU Lesser General Public License, version 2.1, GNU General Public License, version 2.0 |
| Dracos | — | — | — |
| Dragora GNU/Linux-libre | — | — | GNU General Public License |
| Dreamlinux | — | — | GNU General Public License |
| Droidian | — | — | — |
| DSLinux | — | — | GNU General Public License |
| DuZeru | — | — | — |
| Dynebolic | — | — | GNU General Public License |
| E/OS | — | — | GNU General Public License, version 2.0 |
| EasyNAS | — | — | — |
| EasyOS | — | — | — |
| EasyPeasy | — | — | GNU General Public License |
| Edubuntu | Canonical Ltd. | — | GNU General Public License |
| EducaAndOS | — | — | — |
| Educanix | — | — | GNU General Public License |
| Eduknoppix | — | — | GNU General Public License |
| EduLinux | — | — | — |
| Elbuntu | — | 2006 | GNU General Public License |
| Elementary OS | — | — | GNU Lesser General Public License, GNU General Public License |
| ELinOS | SYSGO | — | GNU General Public License |
| Elive | — | — | GNU General Public License |
| Emmabuntüs | — | — | — |
| EndeavourOS | — | 2019 | — |
| Endian Firewall | — | — | GNU General Public License |
| Endless OS | Endless Computer | — | — |
| EnGarde Secure Linux | — | — | — |
| Enlisy | — | — | — |
| Enso OS | — | — | GNU General Public License |
| Escuelas Linux | — | — | — |
| Estobuntu | — | — | — |
| Estrella Roja | — | — | — |
| EterTICs GNU/Linux | — | 2014 | — |